WP3 leader. Mainly contributing to WP4, WP6 and WP8 and contributing to WP1, WP5, WP7 and WP9.

MUG will contribute to the project by providing reference methods and validation know how for real time and on-line measurement technologies.

MUG provides its knowledge of on-line and real-time sample characterization of particle streams based on an innovative new technology OptoFluidic Force Induction (OF2i) recently developed at the GSRC NM-Lab Graz. The OF2i technology is based on optofluidics and combines microfluidics and bio-photonics to characterize and manipulate nanoparticles.

The innovative OF2i technology is well established and tested at the NM-Lab in Graz (TRL 4) and currently in translation through the spinoff BRAVE Analytics GmbH from the Medical University of Graz (MUG). OF2i inline measurements will be compared and validated through state-of-the-art stationary reference characterization methodologies through the established PaLab-Graz (Particle Characterisation Lab Graz).

The Gottfried Schatz Research Center (GSRC) provides the adequate space for research, industrial research and translation in an interdisciplinary scientific environment. The research fields of the Division of Biophysics include molecular physiology, quantitative cell biology, computational modelling and nanomedicine. The Nanomedicine Lab (NM-Lab) offers specialized know how in the field of particle characterisation, microfluidics and bio photonics. NM-Lab, as partner and coordinator of the “3 University consortium” Particle Characterisation Lab Graz (PaLab-Graz) has privileged access to additional complementary state-of-the-art technologies. The close relation and local proximity to the networking organisation BioNanoNet (consortium partners), as well as Graz as one of the leading Bio-Tech-Med science-city hotspots in Europe provides additional value.

MUG contributes in the following areas of research: Process evaluations/optimization through OF2i measuring equipment development. Validation and inter-technology comparisons through state-of-the-art stationary reference characterization methodologies (DLS, NTA, SAXS, TEM, SEM).

Within the project, the following contributions will be made: Lab space for RTO lab scale PAT-implementations, evaluating inline measurement technologies for specific particle parameters (e.g. real time aggregation behaviour, size distribution, …).